SLC36 family of proton-coupled amino acid transporters in GtoPdb v.2021.3

Members of the SLC36 family proton-coupled amino acid transporters are involved in membrane transport acids and derivatives. The four show variable tissue expression patterns expressed various cell types at plasma-membrane intracellular organelles. PAT1 is luminal surface small intestine absorbs derivatives [3]. In lysosomes, functions as an efflux mechanism for produced during intralysosomal proteolysis [2, 18]. PAT2 apical renal proximal tubule [6] brown/beige adipocytes [20]. PAT4 regulation mTORC1 pathway [11]. More comprehensive lists substrates can be found within reviews under Further Reading references